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, wherein R 6 is methyl and R 6′ is hydroxy); dehydrodoxycycline (eg, wherein R 4 is NR 4aR 4b; R 4a and R 4b are methyl, R 5 is hydroxyl, R 4′ and R 5′ are hydrogen, and X is CR 6R 6′, wherein R 6 is methyl and R 6′ is hydrogen); dehydrominocycline (wherein R 4 is NR 4aR 4b; R 4a and R 4b are methyl; R 4′, R 5′, and R 5 are hydrogen and X is CR 6R 6′ wherein R 6 and R 6′ are hydrogen atoms, and R 7 is dimethylamino); or dehydrosancycline (wherein R 4 is NR 4aR 4b; R 4a and R 4b are methyl; R 4′, R 5′, and R 5 are hydrogen and X is CR 6R 6′ wherein R 6 and R 6′ are hydrogen atoms?

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